Vagal Bio

Cognitive Restoration via the Gut-Brain Axis

A first-in-class phage-probiotic symbiotic for age-related cognitive decline.

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A Trillion-Dollar Crisis

55M+

People worldwide living with dementia.

$1.3T

Annual global cost of dementia care.

99.6%

Failure rate of Alzheimer's drug clinical trials targeting amyloid/tau.

The Discovery: The Gut-Memory Brake

A March 2026 Nature paper reveals the real driver of memory loss is in the gut.

Pathobiont Rise: P. goldsteinii levels increase in the gut microbiome with age.
MCFA Production: This bacterium produces medium-chain fatty acids (MCFAs).
Vagal Impairment: MCFAs trigger IL-1β inflammation, which impairs vagal signaling to the hippocampus, causing memory loss.

The Solution: 'Clear and Colonize'

Vagal Bio utilizes a dual-mechanism symbiotic to break the cycle of decline:

1. CLEARTargeted lytic bacteriophages destroy P. goldsteinii, cutting MCFA production at the source.

2. RESTOREReducing MCFAs lifts growth inhibition on Bifidobacterium, creating a permissive niche.

3. COLONIZECo-administered Bifidobacterium repairs tight junctions and suppresses barrier breakdown.

The Strategic Synergy: GLP-1 Opportunity

GLP-1 receptor agonists (Ozempic/Wegovy) push the vagal signal. Vagal Bio removes the "brake". This dual-intervention approach represents a $50B+ partnership opportunity.

Ready to Lead the Next Frontier?

Founding Team & Contact:

Bashir Anastas, Founder
bashir.anastas@gmail.com | 510-830-8804

Provisional Patents Filed, March 2026. Confidential.